Immunophenotyping in Chronic Myeloid Leukemia Blast Crisis: Looking beyond Morphology
نویسندگان
چکیده
منابع مشابه
Erythroid blast crisis of chronic myeloid leukemia.
70-year old woman was admitted with a diagnosis of pyelonephritis. The physical examination showed her to be lethargic and febrile (39°C). There was no liver or spleen enlargement. Laboratory findings were as follows: white blood cell count: 25310, hemoglobin level: 11.2 g/dL, platelet count: 41310/L, lacticodehydrogenase level: 4,100 IU/L (normal value < 350); erythrocyte sedimentation rate: 9...
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Background: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder due to BCR-ABL1 translocation. Patients showing transformation into blast crisis (BC) have poorer treatment response and prognosis. Methods: A retrospective study was conducted in the department of Pathology, Maulana Azad Medical College, New Delhi, India, over a time period of 5 years (2014-2019) to evaluate the ...
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A 32-yr-old man with the chronic phase of chronic myeloid leukemia (CML-CP) was treated with imatinib mesylate for 6 mo. The real-time quantitative reverse transcription PCR ratio for BCR/ABL in blood mRNA (BCR/ABL RT-QPCR) decreased from an initial value of 0.0159 to a low value of 0.0012 after 3 mo, indicating complete hematologic response. During the next 3 mo, the patient progressed to a pr...
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Chronic myeloid leukemia (CML) progresses through three distinct clinical stages: chronic phase, accelerated phase, and blast crisis. The progression to accelerated phase and blast crisis is driven by activation of oncogenes, inactivation of tumor suppressor genes, and/or amplification of the BCR-ABL fusion gene, which causes the chronic phase of the disease. The cell of origin of blast crisis ...
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karyocyte colony formation. These data indicate that the IgG autoantibodies can specifically neutralize the in vitro biologic activity of TPO. The effectiveness of cyA in improving thrombocytopenia strongly suggests an immune-mediated pathogenetic mechanism in the patient. Although it is unclear that anti-TPO autoantibody is the sole cause of the thrombocytopenia, the recovery of serum TPO leve...
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ژورنال
عنوان ژورنال: Journal of Postgraduate Medicine, Education and Research
سال: 2016
ISSN: 2277-8969,2278-0262
DOI: 10.5005/jp-journals-10028-1215